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M94A3149.TXT
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1994-10-25
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Document 3149
DOCN M94A3149
TI Interaction of HIV-1 and HHV-6 in human T-cell line.
DT 9412
AU Takasaki T; Yamaguchi J; Ohkawa N; Sano K; Nakano T; Nakai M; Dept. of
Bacteriology, Kinki Univ. School of Medicine, Osaka,; Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):141 (abstract no. PA0183). Unique
Identifier : AIDSLINE ICA10/94369426
AB OBJECTIVE: This study morphologically investigates the interaction of
HIV-1 and HHV-6 in human T-cell line. METHODS: HIV-1 was inoculated to
Molt-4 and MT-4 cells infected with HHV-6 in 7 days after HHV-6
infection, and continued to culture for another 7 and 10 days. The
infection of HIV-1 and HHV-6 were monitered by non-RI RT assay (Nakano
et al.) for cultured supernatant and PCR assay (Primer: HHV-101, Genemed
Bio.) for the cell. After the culture, the infected cells were observed
with a transmission electron microscope. RESULTS: The cells were divided
into a destructive and an intact types. The former typed cell was filled
with herpes type particles, but less number of HIV-1 particles were
detected on the surface of the cell. Most of the later typed cell
produced HIV-1 particles with budding, and a less number of HHV-6
particles in the cell. But some intact cells with a lot of HHV-6
particles produced a less number of HIV-1 particles. CONCLUSION: HIV-1
can superinfect to HHV-6 producing cell. HIV-1 superinfection to HHV-6
infected cell induces drastic cytopathic effect.
DE Cell Line DNA Primers Herpesvirus 6,
Human/GENETICS/*PHYSIOLOGY/ULTRASTRUCTURE Human
HIV-1/GENETICS/*PHYSIOLOGY/ULTRASTRUCTURE Kinetics Microscopy,
Electron Polymerase Chain Reaction/METHODS T-Lymphocytes/*MICROBIOLOGY
Time Factors MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).